Discusses the diagnostic potential of circulating MicroRNAs

Presents hypotheses on the potential biological relevance of circulating microRNAs

Highlights the role of circulating microRNAs in epigenetics, tumor surveillance and interindvidual communication

MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.

"This is an excellent book with good illustrations on circulating microRNAs, given their pathogenic, diagnostic, and potential therapeutic relevance. The intended audience includes students, researchers, and others in the field of biomedicine wishing to learn more about microRNAs. The book should also prove quite interesting to clinicians who want to understand more about microRNAs given their relevance in diagnostics and therapeutics. The author is a credible authority in this field." (Omer Iqbal, Doody's Book Reviews, September, 2016)