As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular Biology? series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls.
Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.
From the reviews:
"This book provides a collection of over 50 applications of GC-MS, LC-MS, and ICP-MS for screening, identification, and quantification of clinically relevant analytes in body samples. ? It can be recommended ? to critical practitioners in laboratory medicine." (Hans H. Maurer, Analytical and Bioanalytical Chemistry, Vol. 399, 2011)
"Clinical Applications of Mass Spectrometry Methods and Protocols is a compilation of ready-to-use protocols for the determination of clinically relevant analytes in various biological matrices. ? the book is a straightforward compilation of diverse protocols written in a very user-friendly format. It is especially valuable for labs that have just started implementing mass spectrometry or for those planning to do so in the near future. For labs with more experience in mass spectrometry, the protocols can save many hours of precious method development time." (Robert Jansen, Journal of the American Society for Mass Spectrometry, Vol. 22, 2011)
