Maine Hudson has a high tolerance for pharmaceuticals and a low tolerance for everything and everyone else. This includes his Greek parents, who bankroll his glorious isolation in London. This includes his career as a consultant, his clients, his boss, the majority of his colleagues and people he sees on the way to work. This includes the dumb model boyfriend of the American girl that he has decided to fall in love with. This includes her also. When Maine fails to obliterate himself through drug overdoses, the obsessive changing of his legal name and half-hearted thoughts of suicide, it falls to his central nervous system to pick up the challenge of trying to kill him off. Can Maine survive with his lack of values intact?