In this book, the author explains the most recurrent endemic, epidemic and pandemic diseases such as cholera, Ebola, COVID-19, typhoid fever, malaria and HIV/AIDS. This book demonstrates that these diseases that decimate the human race are preventable through the implementation of water, hygiene and sanitation activities, with the aspect of cross-cutting activities to fight malaria and HIV/AIDS. Based on his field experience, the author has adapted the intervention against these different diseases from the higher to the basic level so that the book is beneficial to all social strata. The knowledge of the mode of contamination of these diseases explained in this book will lead the reader to appropriate the knowledge of an effective fight against the diseases mentioned in this book and by ricochet, several other communicable diseases.