The characteristic pathologic feature of UC is infiltration of the intestine by mononuclear cells, predominantly lymphocytes. Current research is directed to Vitamin D and its role in the disease activity in patients with IBD. The aim of the present study is to investigate the serum level of vitamin D and other biomarkers e.g. adhesion molecules in patients diagnosed with UC and determining the statistical correlation of these molecules with each other and ultimately with endoscopic severity of UC.