1,3,4-thiadiazole is one of the most potent heterocyclic containing carbonic anhydrase and antibacterial inhibitor from the natural and synthetic origin. It possessed potent anticonvulsant activity in wide range preclinical in vitro and in vivo models. Recently, various 1,3,4-thiadiazole derivatives have been synthesized and evaluated their anticonvulsant activity. This review is a demonstration to compile the medicinal chemistry, anticonvulsant screening and their structural activity relationship as well as pharmacophoric pattern of various synthesized 1,3,4-thiadiazole derivatives.