Leg ulcer is multifactorial disease with several known acquired and inhereted predisposing factors. In some cases, besides the characteristic acquired etiological factor such as venous insufficiency, there is a putative inherited etiological factor, which also contributes to the mechanism of delayed or pathologic wound healing and thus to the development of leg ulcer. Therefore the delineation of the molecular mechanisms of pathologic wound healing might lead to the development of causative treatment opportunities for the therapy-resistant forms.