Management, Operation, and Program Development in Human Services Organizations: EnvisionSMART(TM): A Melmark Model of Administration and Operation is the fourth guidebook in the EnvisionSMART(TM) series addressing leadership and management practices in human services organizations for persons with intellectual and developmental disabilities. The authors describe a model of administration and operation formed from the disciplines of applied behavior analysis (ABA) and organizational behavior management (OBM). Critical components of organizational design and responsiveness are presented, with chapters devoted to behavior, clinical, and health safety, diversity-equity-inclusion (DEI), assessment and evaluation, and practice-research dissemination. The guidebook illustrates systems-wide implementation of assessment, measurement, intervention and evaluation procedures, includes many practice protocols, and details the evidence-support for programmatic recommendations.