The most recent report of World Health Organization (WHO) considered the Depression as a prime cause for disability across the globe. It is commonly presents with loss of intrigue, depressed mood, decreased energy, sentiments of guilt, disturbed sleep or appetite, poor focus and anxiety. Therapeutic Listening is one of the emerging techniques which uses electronic modifications, along with the organized, rhythmical sound patterns in music, to stimulate neuroplasticity within the nervous system. However, there is minimal evidence that currently measures the outcomes of these interventions on depression consistently. Thus, this book is focused on exploring the effect of therapeutic listening on severity of depression and quality of life in institutionalized adolescent.