Cancer is an important public health problem in many parts of the world, and oral cancer is the second most common cancers worldwide. Uncontrolled cell proliferation is one of the main hallmarks of cancer, and the tumor cells that have acquired damage to genes are directly involved in regulating the cell cycle. Despite the newest techniques with lights, rinses and various tests, the gold standard in any unexplained findings is biopsy for microscopic confirmation. Increased and abnormal mitotic figures indicate genetic damage. Thus identification and quantification of mitotic figures forms an indispensible part of histopathological diagnosis and thus the treatment of OSCC. Therefore, mitotic figure counting is widely used in pathological diagnosis,to assess rate of proliferation of the carcinoma and is also valuable in the assessment of prognosis.The book is written in an engaging style and would prove helpful to those interested in the subject. It will whet the appetite for further investigation and research in the field.