Sexuality, defined as the aspect of every social person that includes not only the erotic act, but also the emotionality and capacity of expression of this, sexual orientation, the gender role that is decided to play, among others, is not only exclusive to those who call themselves neurotypical, but also every person from adolescence onwards, including those who have some degree of disability can experience it. This book was born as an experience to explore from the clinical and bibliographic aspect how sexuality is experienced in adolescents with Autism Spectrum Disorder (ASD) from its clinical aspects, parents as a family nucleus and as a guide on responsible sexuality and the difficulties of this topic.