The prime objective of the book is to put forward ideas that come from observation, critical thinking and applications based on research outcomes, from the perspective of people who study and actively participates in life in the Amazon. The motive is to start a discussion on the sustainability issues of the region in particular and globe in general. It also offers an opportunity to contribute and promote reflections by researchers and stakeholders, aiming together to think of a strategic plan for the sustainable development in the region. This contemporary study has focused on an approach of sustainability based on management of innovation, the management of cities, organizational and socio-economic development aiming to improve-quality of life on the planet. This will definitely help to promote innovation based and improved processes and procedures to achieve sustainability in the region.