This book will contain the papers presented at the 28th International Conference on Production Research 2025. The ICPR2025 conference will be held at Universidad de La Sabana, Chia, Colombia, in July 12-17, 2025. The book focuses on the latest advancements in production research to identify key trends and innovations in areas such as sustainable manufacturing, production planning, healthcare, machine learning and supply chain optimization. Chapters published in this book will cover new theories, with emphasis on digital and smart manufacturing, lean and agile manufacturing, sustainable manufacturing and engineering.