This open access book addresses the urgent need to redesign entrepreneurship education for a hybrid, physical-digital world. It introduces the concept of phygital hubs-integrated environments combining physical interaction and digital technology-as transformative infrastructures for developing entrepreneurial skills, fostering inclusion, and generating measurable impact. Grounded in ecosystem theory, business model design, and human-centered innovation, the book proposes a scalable framework for inclusive, data-driven education. It explores how AI, immersive learning, and personalization empower disadvantaged groups and enhance engagement. Combining conceptual chapters with practical tools and case studies, the volume offers educators, policymakers, and researchers actionable strategies to bridge skills gaps, democratize access, and promote sustainable regional development in the post-pandemic digital era.